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Perl 6 to machine code via Common Lisp and sbcl
Hello world is about the only thing the CL backend is currently compiling, but it's doing so quite impressively already. I've posted an update to a recent thread on pugs.blogs.com that shows how fast Perl 6 to machine code via sbcl is doing compared to the kp6 perl5 backend and the parrot nqp compiler.
Common Lisp has other implementations you could do some interesting stuff with, for instance you could run the same program under movitz "on the metal". If someone wanted to implement an operating system in Perl now would be a good time to start:)