Yesterday I went to an israel.pm meeting at Tel Aviv University to hear a lecture by Gabor Szabo on Padre.
Other than meeting Gabor and Shlomi Fish in person and a few other mongers (all really nice people), I did not hear a lot of new things about Padre (since I already dabbled with it a bit) but some things were very interesting. Basically at some point, Gabor suggested that Padre could be used as a instrument for small GUI applications. That caught my attention.
Imagine having a CVS/SVN/git interface that helps you update your repository from within Padre. Imagine having a plugin that creates a textual graph of your program, imagine a plugin that creates a visual graph of your program.
Now, recall Firefox extensions. This is what Padre allows you.