I've never been a fan of Joel's writing, but he kind of clinched the deal with this one. To quote:
...the bottom line is that there are three and a half platforms (C#, Java, PHP, and a half Python) that are all equally likely to make you successful, an infinity of platforms where you're pretty much guaranteed to fail spectacularly when it's too late to change anything (Lisp, ISAPI DLLs written in C, Perl)...
I just hope I can fail as spectacularly as Amazon, Yahoo, and TicketMaster have with their use of Perl.
And incidentally, eBay was originally an ISAPI DLL.