I just caught a link to a programming language benchmark for bioinformatics. Unsurprisingly, the Perl is grotty and the C and C++ and Java implementations beat it handily.
Are there any PDLlers who'd like to bring some sanity to the results? (My eyes are going on strike from the C-style nested loops. Make sure you catch the use of bitwise and as control flow operator. That has to work only by accident.)