The verbose and arcane syntax of POD always distracts me from what I want to write, whenever I write POD directly. I prefer markdown, which doesn't get in the way.
The one thing I commonly need in POD that markdown is lacking, is itemized bulleted lists, that in HTML you'd write with DL/DT/DD lists, and in POD you write as
This is item one.
This is item two.
(Gah! POD is ghastly!)
In a reference manual, I need them a lot.
But, starting from a plain bulleted list, you can get the basic POD list syntax, and by just tweaking the generated POD a little (replacing the bullets with the item text), I get where I want.