Leader of Birmingham.pm [pm.org] and a CPAN author [cpan.org]. Co-organised YAPC::Europe in 2006 and the 2009 QA Hackathon, responsible for the YAPC Conference Surveys [yapc-surveys.org] and the QA Hackathon [qa-hackathon.org] websites. Also the current caretaker for the CPAN Testers websites and data stores.
If you really want to find out more, buy me a Guinness
Once upon a time I would email the ISPs directly and explain the pointlessness of sending a bounce to spam, as virtually all spam contains a spoofed email address. This worked for a few, but seeing as I'm now getting hundreds of these I don't have the time to sit and write to ignorant ISPs .
So, I've written a little script using Net::POP3 to lookup the messages and spot any that might be bounces from emails. The script will then send a one off bounce to that address for each bogus mail account they reply to. The Reply-To is set to email@example.com , so they automatically get blacklisted if they send a reply. We shall over the coming weeks whether this has any effect.
Once I've finished tweaking I may post the code somewhere for others to use or offer advice/patches for enhancements. Perhaps the scripts directory in CPAN might be an idea.
 Okay so they may not all be ignorant, but anyone not ignoring spam in the first place can't be all that bright.
 Mailing to this account would be a bad idea, but you knew that right