Notice the lack of the wide banner add, or the ones on the left. Notice no more Google or Sponsored links. Notice that removing these ads allows me to read a whole extra long paragraph of the story with the same browser size.
Adblock has changed the way I access the web. It's really quite like Tivo: it makes it more efficient for me and thus more fun. I don't know how I could live without it now.
Of course, you have to train Adblock. You have to say, hey, this is an ad, no longer show me things from www.foo.com/ads/. This is relatively easy to do, just right-click on the image, select "Adblock image", edit the regular expression (mmmm, Perly) and see no more ads like that one again.
Oh, I should probably talk about the web developer toolbar at some point too. Anyway, do you have any other adblocking tips?