I gave my YAPC::NA 2008 talk today, Handling the Ball of Mud. The auditorium was big, and the screen was definitely the biggest I have ever given a talk on. I was a bit nervous and went over a couple minutes, but I think it went fairly well
Saw a couple of other great talks. Schwern's Skimmable Code: Fast to Read, Fast to Change had some good insights on "Get in, do your thing, and get out" and "Narrow Focus", and how to use those mantras in writing easy to maintain code.
Ricardo Signes' haunted house themed talk Email Hates the Living! was a very entertaining look at the oddities of the various email RFCs.